NFL odds, lines, picks, spreads, best bets, predictions for Week 5, 2022: Model loving Titans, Jaguars

The Cowboys nation’s reach will likely come into its own on Sunday when Dallas visits the Los Angeles Rams. The Cowboys’ training camp is being held in Southern California, and what should be a divided crowd has the Rams as the 5.5-point home favorites in the latest Week 5 NFL odds from Caesars Sportsbook. Dak Prescott will reportedly not be returning after thumb surgery, leaving Cooper Rush looking to cover one of the week’s bigger NFL spreads.

The Cowboys are 3-1 against the spread this season while the Rams are 1-3. The Week 5 NFL schedule has Cowboys vs. Rams as one of four games with Week 5 NFL Vegas lines greater than a field goal but less than a touchdown. All of the Week 5 NFL lines are listed below and SportsLine’s advanced computer model includes all the NFL betting advice and predictions you need to start making the best Week 5 NFL picks right now.

The model, which simulates every NFL game 10,000 times, has won nearly $7,000 for $100 players with top-tier NFL picks since its inception. The model kicks off Week 4 of the 2022 NFL season with an incredible 139-103 run of top-flight NFL picks that stretches back to the 2017 season.

The model has also ranked in the top 10 on NFLPickWatch in four of the last six years with straight NFL picks, beating more than 94% of CBS Sports football pick ’em players four times in that span. Whoever followed it is way up.

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Now it has turned its attention to the latest Week 5 NFL odds and laid out tips for each NFL matchup. Go here to see each selection.

The best NFL predictions for week 5

One of the strongest NFL picks from the model’s Week 5 is that the Titans (-2.5) cover against the Commanders in almost 60% of the simulations. Washington has one more win than the Houston Texans, but you can argue that the Commanders are the weakest team in the league. They rank 25th in offense and 29th in defense, making them the only team in the bottom 10 of both categories.

Meanwhile, Tennessee has rediscovered the formula that allowed them to finish as the AFC’s No. 1 last year. The team has won its last two games and put it back, thanks to Derrick Henry reclaiming his throne as arguably the best running back in the league. Henry has racked up over 140 scrimmage yards in consecutive weeks despite facing two top 10 run defenses. Tennessee ties as a 2.5 point favorite in almost 60% of the simulations.

Another Week 5 NFL prediction: The Jaguars (-7) cover at home in a divisional matchup against the Texans. Jacksonville has only played one home game so far, a 24-point shutout win over the Colts. Jacksonville sits in third place by a plus 38 points, arguably behind only the NFL’s top two teams, the Bills and Eagles.

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The Jags fell to Philly in Week 4 thanks to wet conditions that resulted in four lost fumbles by Trevor Lawrence. That was certainly a runaway of a game, given that Lawrence has had just three lost fumbles in his last 17 games combined. The Jags have top-10 offense and top-10 defense, while Houston is in the bottom half of the league in both categories. Jacksonville is expected to gain double digits and cover well over 50% of the simulations. The model also has the Under (44.5), which hits well over 50 percent of the time. See which other teams you should pick here.

How to make NFL picks for week 5

The model has also called who will win and cover in every other game on the Week 5 NFL schedule, and it also says an underdog is in for a big upset. You can get every selection for every game only at SportsLine.

So what NFL tips can you hit with confidence? And which outsider causes a big surprise? Check out the latest NFL odds below, then visit SportsLine to see which teams are winning and cover the range, all from a proven computer model that has grossed nearly $7,000 since inception, and find it out.

Week 5 NFL odds, lines, spreads

Get full NFL picks at SportsLine

Thursday October 6th

Stallions at Broncos (-3, 42)

Featured Game | Denver Broncos vs. Indianapolis Colts

Sunday October 9th

Giants at Packers (-8, 41)

Steelers at Bills (-14, 46.5)

Featured Game | Buffalo Bills versus Pittsburgh Steelers

Chargers at Browns (+2.5, 47.5)

Featured Game | Cleveland Browns vs. Los Angeles Chargers

Texans at Jaguars (-7, 43.5)

Featured Game | Jacksonville Jaguars vs. Houston Texans

Bears at Vikings (-7, 44)

Featured Game | Minnesota Vikings vs. Chicago Bears

Lions at Patriots (-3, 45.5)

Featured Game | New England Patriots vs. Detroit Lions

Seahawks at Saints (-5.5, 46)

Featured Game | New Orleans Saints vs. Seattle Seahawks

Dolphins at Jets (+3.5, 46)

Featured Game | New York Jets versus Miami Dolphins

Hawks on Buccaneers (-9, 48)

Featured Game | Tampa Bay Buccaneers vs. Atlanta Falcons

Titans at Commanders (+2.5, 42.5)

Featured Game | Washington Commanders vs. Tennessee Titans

49ers at Panthers (+6.5, 39)

Featured Game | Carolina Panthers vs. San Francisco 49ers

Eagles in Cardinals (+5, 49)

Featured Game | Arizona Cardinals vs Philadelphia Eagles

Cowboys at Rams (-5.5, 42.5)

Featured Game | Los Angeles Rams vs. Dallas Cowboys

Bengal at Ravens (-3, 48.5)

Featured Game | Baltimore Ravens vs. Cincinnati Bengals

Monday 10 October

Raiders at Chiefs (-7, 51)

Featured Game | Kansas City Chiefs vs. Las Vegas Raiders

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