Live longer: Polyphenols in green tea may activate longevity gene seen in people living to

Tea has caught the world’s attention for its beneficial effects on health, such as reducing inflammation and helping to fight cancer. It has also been associated with the expression of FOXO3A, which has been called the “longevity gene” because it is more prominent in centenarians. Researchers have found that by preventing cell damage, green tea consumption can reduce the risk of death for some people by up to 82%.

FOXO3 is a key player in the control of skeletal muscle proteins and is a critical regulator of protein synthesis and degradation in muscle.

It is believed to have a strong influence on aging and age-related phenotypes, as it modulates the stress response, which affects lifespan.

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Science Direct explains: “A significant association has been demonstrated between longevity and several variations of the FOXO3 gene.”

This observation is supported by several studies investigating the association between green tea consumption and all-cause mortality among older people.

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As a whole, these large cohort studies and meta-analyses have yielded varying results.

One thing they have in common, however, is that they all found significant reductions in all-cause mortality among green tea habituated users.

More specifically, one of the studies published in JAMA in 2006 showed that people who consumed the largest amount of green tea reduced their cardiovascular risk by up to 82 percent.

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The findings showed that those who drank at least five cups of green tea a day were 76 percent less likely to die than those who did not.


A meta-analysis published by the health agency highlights that many studies have found a link between EGCG and a reduced incidence of cancer.

The authors explained: “We observed a significant increase in the mean latency to the first tumor, an approximately 70 percent reduction in tumor burden, and an 87 percent reduction in the number of invasive tumors per tumor-bearing animals. […] groups of rats drinking green tea.

“Similar protection was seen in other animal cancer models, including prostate, skin, and lung.”

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Elsewhere, the report notes that there is evidence of “inducing expression of FOXO3A” and its target gene in ECGC therapy.

This evidence indicates that FOXO3A can both act as a tumor suppressor in cancer and reduce the risk of all-cause mortality.

Doctor Bradley Willcox, principal investigator of the National Aging Fund Kuakini Hawaii Lifespan Study Institute, had previously listed several foods that may help activate the longevity gene.

According to the expert, these may include sweet potatoes, turmeric, and sea-based carotenoid-rich foods such as seaweed and seaweed.

Besides ECGC, vegetables rich in the marine photoactive compound astaxanthin have also been shown to express this gene.


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